Robustness Perspective on Network-based Prediction of Gene Essentiality

被引：0
|
作者：
Liu, Wei [1 ]
Ding, Dewu [2 ]
Li, Nawen [3 ]
机构：
[1] Ludong Univ, Dept Modern Educ Technol & Teaching, Yantai 264025, Peoples R China
[2] Chizhou Coll, Dept Math & Comp Sci, Chizhou 247000, Peoples R China
[3] Guilin Univ Elect Technol, Dept Design, Guilin 541004, Peoples R China
来源：
CCDC 2009: 21ST CHINESE CONTROL AND DECISION CONFERENCE, VOLS 1-6, PROCEEDINGS | 2009年
关键词：
Gene Essentiality; Metabolic Network; Robustness;
D O I：
10.1109/CCDC.2009.5191705
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
Essential genes are the genes that are indispensable to cell viability. It is very important to ascertain these genes for understanding the biological phenomena, as well as drug and therapy design. In the present paper, we understand the essential and nonessential genes from the perspective of robustness. Other than traditional homology study based methods, this article use structural analysis of functional subsystems of genome-scale metabolic networks. We give the structural analysis of the citric acid cycle as a case study, the result suggests that this systems-oriented method would help to ascertain gene essentiality.
引用
收藏
页码：3871 / +
页数：2
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