Ligand-free copper-catalyzed direct amidation of diaryliodonium salts using nitriles as amidation reagents

被引：6

作者：

Cheng, Hui-cheng ^{[1
]}

Zhou, Lichao ^{[1
]}

Zhou, Xuming ^{[1
]}

Ma, Jiao-li ^{[1
]}

Guo, Penghu ^{[1
]}

Zhang, Yang ^{[1
]}

Ji, Hong-bing ^{[1
,2
]}

机构：

[1] Guangdong Univ Petrochem Technol, Coll Chem, Maoming 525000, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem, Fine Chem Ind Res Inst, Guangzhou 510275, Peoples R China

来源：

TETRAHEDRON LETTERS | 2021年 / 71卷

基金：

中国国家自然科学基金;

关键词：

Copper catalyst; Diaryliodonium salts; N-Arylamides; Synthesis; Amidation; N BOND-FORMATION; CROSS-COUPLING REACTIONS; POTASSIUM TERT-BUTOXIDE; C-H AMINATION; CYCLIC DIARYLIODONIUM; CASCADE ANNULATION; INSERTION; ACIDS; DERIVATIVES; ARYLAMIDES;

D O I：

10.1016/j.tetlet.2021.153048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and practical methodology for the synthesis of N-arylamides has been developed via coppercatalyzed amidation of diaryliodonium salts with nitriles. Various substituted aryl nitriles and aliphatic nitriles could be applied in the reaction, providing a series of N-arylated amides in moderate to good yields. This procedure provides an alternative route for the synthesis of various N-arylamides. A proposed mechanism based on control experiments is also presented. (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：5

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