Regulation of angiogenesis by ETS transcription factors

被引：59

作者：

Randi, Anna M. ^{[1
]}

Sperone, Andrea ^{[1
]}

Dryden, Nicola H. ^{[1
]}

Birdsey, Graeme M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Natl Heart & Lung Inst, Cardiovasc Sci Unit, London W12 0NN, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷

关键词：

angiogenesis; endothelial cell; endothelial homoeostasis; ETS transcription factor; gene expression; ENDOTHELIAL-CELL DIFFERENTIATION; OXIDE SYNTHASE GENE; VASCULAR DEVELOPMENT; FACTOR ERG; TUMOR ANGIOGENESIS; VE-CADHERIN; TIE2; GENE; IN-VIVO; EXPRESSION; FAMILY;

D O I：

10.1042/BST0371248

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally, we discuss novel evidence that shows how these transcription factors act in a combinatorial fashion with others, through composite sites that may be crucial in determining endothelial specificity in gene transcription.

引用

页码：1248 / 1253

页数：6

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