Pharmacokinetics of Itraconazole in Diabetic Rats

被引：4
|
作者：
Lee, Unji [1 ]
Choi, Young H. [2 ,3 ]
Kim, So H. [4 ,5 ]
Lee, Byung K. [1 ]
机构：
[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[3] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea
[4] Kangnung Wonju Natl Univ, Dept Pharmacol, Coll Dent, Kangnung 210702, Kyunggi Do, South Korea
[5] Kangnung Wonju Natl Univ, Res Inst Oral Sci, Kangnung 210702, Kyunggi Do, South Korea
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 02期
关键词：
MELLITUS;
D O I：
10.1128/AAC.01145-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
After intravenous or oral administration of 10 mg/kg itraconazole to rats with streptozotocin-induced diabetes mellitus and to control rats, the total area under the plasma concentration-time curve from time 0 to 24 h (AUC(0-24)) for itraconazole and that for its metabolite, 7-hydroxyitraconazole, were similar between the two groups of rats. This may be explained by the comparable hepatic and intestinal intrinsic clearance rates for the disappearance of itraconazole and the formation of 7-hydroxyitraconazole in both groups of rats.
引用
收藏
页码：931 / 933
页数：3
相关论文
共 50 条
  • [41] Effect of clarithromycin and itraconazole on the pharmacokinetics of ropivacaine
    Jokinen, MJ
    Ahonen, J
    Neuvonen, PJ
    Olkkola, KT
    [J]. PHARMACOLOGY & TOXICOLOGY, 2001, 88 (04): : 187 - 191
  • [42] Itraconazole, gemfibrozil affect loperamide pharmacokinetics
    [J]. Reactions Weekly, 2006, 1114 (1) : 4 - 4
  • [43] ITRACONAZOLE PHARMACOKINETICS IN PATIENTS WITH RENAL DYSFUNCTION
    BOELAERT, J
    SCHURGERS, M
    MATTHYS, E
    DANEELS, R
    VANPEER, A
    DEBEULE, K
    WOESTENBORGHS, R
    HEYKANTS, J
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (10) : 1595 - 1597
  • [44] Itraconazole oral solution: Pharmacokinetics and absorption
    Saag, M
    [J]. AIDS PATIENT CARE AND STDS, 1997, 11 : S16 - S17
  • [45] The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib
    Vishwanathan, Karthick
    Dickinson, Paul A.
    So, Karen
    Thomas, Karen
    Chen, Yuh-Min
    De Castro Carpeno, Javier
    Dingemans, Anne-Marie C.
    Kim, Hye Ryun
    Kim, Joo-Hang
    Krebs, Matthew G.
    Yang, James Chih-Hsin
    Khanh Bui
    Weilert, Doris
    Harvey, R. Donald
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2018, 84 (06) : 1156 - 1169
  • [46] Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem
    Luurila, H
    Kivistö, KT
    Neuvonen, PJ
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 54 (02) : 163 - 166
  • [47] The safety of itraconazole in the diabetic population
    Albreski, DA
    Gross, EG
    [J]. JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 1999, 89 (07) : 339 - 345
  • [48] Pharmacokinetics of Genistein distribution in blood and retinas of diabetic and non-diabetic rats
    Mahmoud, ME
    de Juan, E
    Cooney, M
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U283 - U283
  • [49] Pharmacokinetics of genistein distribution in blood and retinas of diabetic and non-diabetic rats
    Hakami, T.
    Mahmoud, M. I.
    de Juan, E.
    Cooney, M.
    [J]. DRUG METABOLISM AND PHARMACOKINETICS, 2021, 39
  • [50] Safety of itraconazole in diabetic patients
    Verspeelt, J
    Marynissen, G
    Gupta, AK
    De Doncker, P
    [J]. DERMATOLOGY, 1999, 198 (04) : 382 - 384
12345