Methodological problems of the influence of antiepileptic drugs (AED) on epileptic seizures are characterized. An analysis of 505 patients with diagnosis of pharmacoresistant epilepsy has been conducted. In 187 (37%) patients the causes of treatment resistance were as follows: overtreatment (73 patients; 14,5%), inadequate AED prescription potentially predicted effects - (69 patients; 13,7%), paradoxical reactions to AED (45 patients; 8,9%). Inadequately prescribed were mostly carbamazepine and phenytoin and the drug with paradoxical effect - valproate.
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Ankara City Hosp, Childrens Hosp, Dept Pediat Neurol, Ankara, TurkiyeAnkara City Hosp, Childrens Hosp, Dept Pediat Neurol, Ankara, Turkiye
Gultutan, Pembe
Nalcacioglu, Pinar
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Ankara Yildirim Beyazit Univ, Dept Ophthalmol, Ankara, Turkiye
Ankara Yildirim Beyazit Univ, Dept Ophthalmol, Med Sch, Univ Mahallesi 1604 Sokak 9, Ankara, TurkiyeAnkara City Hosp, Childrens Hosp, Dept Pediat Neurol, Ankara, Turkiye
Nalcacioglu, Pinar
Icoz, Mehmet
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Yozgat City Hosp, Dept Ophthalmol, Yozgat, TurkiyeAnkara City Hosp, Childrens Hosp, Dept Pediat Neurol, Ankara, Turkiye
Icoz, Mehmet
Yilmaz, Deniz
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Ankara City Hosp, Childrens Hosp, Dept Pediat Neurol, Ankara, TurkiyeAnkara City Hosp, Childrens Hosp, Dept Pediat Neurol, Ankara, Turkiye
Yilmaz, Deniz
Kurt, Aysegul Nese Citak
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Ankara Yildirim Beyazit Univ, Dept Pediat Neurol, Ankara, TurkiyeAnkara City Hosp, Childrens Hosp, Dept Pediat Neurol, Ankara, Turkiye