Neuroprotective Effects of Stem Cells in Ischemic Stroke

被引：37
|
作者：
Xu, Weilin [1 ]
Zheng, Jingwei [1 ]
Gao, Liansheng [1 ]
Li, Tao [1 ]
Zhang, Jianmin [1 ,2 ,3 ]
Shao, Anwen [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurosurg, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Brain Res Inst, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Collaborat Innovat Ctr Brain Sci, Hangzhou, Zhejiang, Peoples R China
来源：
STEM CELLS INTERNATIONAL | 2017年 / 2017卷
基金：
中国博士后科学基金;
关键词：
FOCAL CEREBRAL-ISCHEMIA; MARROW STROMAL CELLS; THERAPEUTIC BENEFIT; FUNCTIONAL RECOVERY; NEURONAL APOPTOSIS; DENTATE GYRUS; UP-REGULATION; ADULT RATS; TRANSPLANTATION; BRAIN;
D O I：
10.1155/2017/4653936
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Ischemic stroke, the most common subtype of stroke, has been one of the leading causes of mobility and mortality worldwide. However, it is still lacking of efficient agents. Stem cell therapy, with its vigorous advantages, has attracted researchers around the world. Numerous experimental researches in animal models of stroke have demonstrated the promising efficacy in treating ischemic stroke. The underlying mechanism involved antiapoptosis, anti-inflammation, promotion of angiogenesis and neurogenesis, formation of new neural cells and neuronal circuitry, antioxidation, and blood-brain barrier (BBB) protection. This review would focus on the types and neuroprotective actions of stem cells and its potential mechanisms for ischemic stroke.
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页数：7
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