Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer'

被引：49
|
作者：
Semkina, Alevtina S. [1 ,2 ]
Abakumov, Maxim A. [1 ,2 ]
Skorikov, Alexander S. [3 ]
Abakumova, Tatiana O. [4 ]
Melnikov, Pavel A. [5 ]
Grinenko, Nadejda F. [5 ]
Cherepanov, Sergey A. [1 ,5 ]
Vishnevskiy, Daniil A. [1 ]
Naumenko, Victor A. [2 ]
Ionova, Klavdiya P. [5 ]
Majouga, Alexander G. [2 ,3 ,6 ]
Chekhonin, Vladimir P. [1 ,5 ]
机构：
[1] Pirogov Russian Natl Res Med Univ, Moscow 117997, Russia
[2] Natl Univ Sci & Technol MISiS, Moscow, Russia
[3] Lomonosov Moscow State Univ, Moscow, Russia
[4] Skolkovo Inst Sci & Technol, Moscow, Russia
[5] Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, Russia
[6] Dmitry Mendeleev Univ Chem Technol Russia, Moscow, Russia
来源：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2018年 / 14卷 / 05期
基金：
俄罗斯科学基金会;
关键词：
magnetic nanoparticles; drug delivery; chemotherapy; MRI-contrast agents; breast adenocarcinoma; iron oxide; ENDOTHELIAL GROWTH-FACTOR; DRUG-DELIVERY; THERAPY; BIODEGRADATION; ANGIOGENESIS; CONJUGATION; LIPOSOMES; MOSSBAUER; TOXICITY; CELLS;
D O I：
10.1016/j.nano.2018.04.019
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In presented paper we have developed new system for cancer theranostics based on vascular endothelial growth factor (VEGF) targeted magnetic nanoparticles. Conjugation of anti-VEGF antibodies with bovine serum albumin coated PEGylated magnetic nanoparticles allows for improved binding with murine breast adenocarcinoma 4T1 cell line and facilitates doxorubicin delivery to tumor cells. It was shown that intravenous injection of doxorubicin loaded VEGF targeted nanoparticles increases median survival rate of mice bearing 4T1 tumors up to 50%. On the other hand magnetic resonance imaging (MRI) of 4T1 tumors 24 h after intravenous injection showed accumulation of nanoparticles in tumors, thus allowing simultaneous cancer therapy and diagnostics. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：1733 / 1742
页数：10
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