Doxorubicin-Loaded Magnetic Silk Fibroin Nanoparticles for Targeted Therapy of Multidrug-Resistant Cancer

被引：215
|
作者：
Tian, Ye [1 ,2 ]
Jiang, Xuejiao [1 ,2 ]
Chen, Xin [1 ,2 ]
Shao, Zhengzhong [1 ,2 ]
Yang, Wuli [1 ,2 ]
机构：
[1] Fudan Univ, State Key Lab Mol Engn Polymers, Dept Macromol Sci, Shanghai 200433, Peoples R China
[2] Fudan Univ, Adv Mat Lab, Shanghai 200433, Peoples R China
来源：
ADVANCED MATERIALS | 2014年 / 26卷 / 43期
基金：
美国国家科学基金会;
关键词：
DRUG-DELIVERY; MULTIFUNCTIONAL NANOPARTICLES; BREAST-CANCER; PH; NANOCARRIERS; REVERSAL; PLATFORM; INSECTS; RELEASE; SYSTEMS;
D O I：
10.1002/adma.201403562
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A strategy to prepare doxorubicin-loaded magnetic silk fibroin nanoparticles is presented. The nanoparticles serve as a nanometer-scale drug-delivery system in the chemotherapy of multidrug-resistant cancer under the guidance of a magnetic field. The magnetic tumor-targeting ability broadens the range of biomedical applications of silk fibroin, and the nanoparticle-assisted preparation strategy is useful for the advancement of other biomacromolecule-based materials.
引用
收藏
页码：7393 / 7398
页数：6
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