Chemical Constituents of Crinum asiaticum L. var. sinicum BAKER and Their Cytotoxic Activities

被引：60

作者：

Sun, Qian ^{[1
]}

Shen, Yun-Heng ^{[1
]}

Tian, Jun-Mian ^{[1
]}

Tang, Jian ^{[1
]}

Su, Juan ^{[1
]}

Liu, Run-Hui ^{[1
]}

Li, Hui-Liang ^{[1
]}

Xu, Xi-Ke ^{[1
]}

Zhang, Wei-Dong ^{[1
,2
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2009年 / 6卷 / 10期

基金：

中国博士后科学基金;

关键词：

ALKALOIDAL CONSTITUENTS; HERB;

D O I：

10.1002/cbdv.200800273

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A phytochemical investigation of the bulbs of Crinum asiaticum L. var. sinicum BAKER resulted in the isolation of two new alkaloids, asiaticumines A and B (1 and 2, resp.), together with 21 known compounds, including nine alkaloids, four amides, five phenolic compounds, and three flavonoids. All 23 compounds were isolated for the first time from Crinum asiaticum L. var. sinicum BAKER. Their structures were elucidated by spectroscopic methods. In addition, ten alkaloids, 1-10, were evaluated for their cytotoxic activities against human tumor cell lines A549, LOVO, HL-60, and 6T-CEM. Compounds 3, 4, and 7-10 selectively showed remarkable inhibition against one or more of the tested cell lines.

引用

页码：1751 / 1757

页数：7

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