Comprehensive Study of Alkaloids from Crinum asiaticum var. sinicum Assisted by HPLC-DAD-SPE-NMR

被引：37
|
作者：
Chen, Chien-Kuang [1 ]
Lin, Feng-Hsu [1 ]
Tseng, Li-Hong [2 ]
Jiang, Chia-Ling [1 ]
Lee, Shoei-Sheng [1 ]
机构：
[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10051, Taiwan
[2] Bruker Biospin GmbH, D-76287 Rheinstetten, Germany
来源：
JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 03期
关键词：
ACTIVE AROMATIC CHROMOPHORE; CONSTITUENTS; IDENTIFICATION; AMARYLLIDACEAE; MS; CHROMATOGRAPHY; HERB;
D O I：
10.1021/np100819n
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A comprehensive study of the alkaloids present in the leaves of Crinum asiaticum var. sinicum, assisted by HPLC-SPE-NMR, led to the characterization of 21 compounds of similar polarity on an analytical scale. Thirteen of these were isolated for further structural confirmation. Seven are proved to be new, namely, (+)-siculine (4), 1-epijosephinine (11), 7-methoxycrinamabine (10), 2-O-acetylcrinamabine (16), 3-O-acetyl-8-O-demethylmaritidine (17), 2-O-acetylbulbisine (18), and 1-O-acetylbulbisine (19). In addition, dihydrovittatine (6) and 8-O-demethyloxomaritidine (21) were isolated for the first time from Nature, although they have been prepared previously as synthetic products. Their structures were established by spectroscopic analysis.
引用
收藏
页码：411 / 419
页数：9
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