Diastereo- and Enantioselective Synthesis of α,γ-Diaminobutyric Acid Derivatives via Cu-Catalyzed Asymmetric Michael Reaction

被引：49

作者：

Li, Qing ^{[1
]}

Ding, Chang-Hua ^{[1
]}

Hou, Xue-Long ^{[1
]}

Dai, Li-Xin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ALPHA-AMINO-ACIDS; CHIRAL CALCIUM COMPLEXES; PHASE-TRANSFER CATALYSIS; PI-ACCEPTOR LIGANDS; AZOMETHINE YLIDES; 1,3-DIPOLAR CYCLOADDITION; CONJUGATE ADDITIONS; GLYCINE DERIVATIVES; NITROALKENES; HYDROFORMYLATION;

D O I：

10.1021/ol100060t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first highly diastereo- and enantioselective catalytic asymmetric Michael addition of glycine derivatives to nitroalkenes have been developed. The enantioselectivity of ortho-substituted products can be significantly improved by using a new 1,2-P,N-ferrocene ligand L5. The alpha,gamma-diaminoacid derivative was obtained without the loss of optical activity from the adduct.

引用

页码：1080 / 1083

页数：4

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