Evaluation of Anticancer Activity of Schiff bases Derived from Pyridine and their Metal Complexes (A Review)

被引：0

作者：

Induleka, R. ^{[1
]}

Chandrika, P. Anushyaveera ^{[1
]}

Tamilselvi, M. ^{[1
]}

Ushanandhini, S. ^{[1
]}

Gowri, M. ^{[1
]}

机构：

[1] Avinashilingam Inst Home Sci & Higher Educ Women, Dept Chem, Coimbatore 641043, Tamil Nadu, India

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2022年 / 38卷 / 03期

关键词：

Pyridine; Metal complexes; Anti cancer activity; Cell viability; IC50; SPECTRAL CHARACTERIZATION; SONOCHEMICAL SYNTHESIS; DFT CALCULATIONS; CD(II); LIGAND; CU(II); ZN(II); NI(II); CO(II); FE(II);

D O I：

10.13005/ojc/380302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is a deadly disease; many treatment strategies are available to cure/treat cancer. After the metal-based anticancer drug (Cisplatin), metal complexes play a vital role in pharmaceutical science. We aimed to analyze the anticancer activity of pyridine Schiff base complexes. This review article searched the anticancer studies of pyridine Schiff base metal complexes from 2015 to 2021. Information was gathered from the selected studies to analyze and highlight the importance of anticancer agents. A total of sixty six full-length articles were collected and evaluated. On the critical assessment, we found that compared to Schiff base ligand, the metal complexes exhibited excellent activity towards various cancer cell lines (including MCF-7, HeLa, HCT-116, Hepa-2). We identified more complexes that exhibited promising activity against various cell lines and revealed IC50 values equal to or even lower than the reference drug used.

引用

下载

页码：517 / 536

页数：20

共 50 条

[41] Synthesis and characterization of some bivalent metal complexes of schiff bases derived from as-triazine
Singh, G
Singh, PA
Sen, AK
Singh, K
Dubey, SN
Handa, RN
Choi, JH
SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 2002, 32 (01): : 171 - 187
[42] SYNTHESIS AND TESTING OF METAL COMPLEXES OF QUINOXALINE BASED SCHIFF BASES FOR ANTIMICROBIAL AND ANTICANCER ACTIVITIES
Manchal, Ravinder
Kasula, Mamatha
Muthadi, Srujana
Kumari, K. V. N. G.
Somu, Srihari
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2015, 6 (02): : 698 - 704
[43] Synthesis, characterization, anticancer and antimicrobial studies of metal nanoparticles derived from Schiff base complexes
Mahdi, Saba H.
Karem, Lekaa K. Abdul
INORGANIC CHEMISTRY COMMUNICATIONS, 2024, 165
[44] Anticancer properties of new metal complexes derived from a polydentate azo-schiff base
Sahan, F.
Kose, M.
Hepokur, C.
Kurtoglu, M.
FEBS JOURNAL, 2016, 283 : 377 - 377
[45] Chiral Oxazolidine Complexes Derived from Phenolic Schiff Bases
Mayans, Julia
Gomez, Daniel
Font-Bardia, Merce
Escuer, Albert
CRYSTAL GROWTH & DESIGN, 2020, 20 (06) : 4176 - 4184
[46] Solvent-free synthesis, characterization, biological activity of schiff bases and their metal (II) complexes derived from ferrocenyl chalcone
Liu, Yuting
Yang, Lisha
Yin, Dawei
Dang, Yang
Yang, Lan
Zou, Qian
Li, Jie
Sun, Jiaxi
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2019, 899
[47] BIOLOGICAL-ACTIVITY OF SCHIFF-BASES AND THEIR METAL-COMPLEXES
BHARAMAGOUDAR, TD
PUJAR, MA
ALAGAWADI, AR
CURRENT SCIENCE, 1987, 56 (17): : 889 - 890
[48] Synthesis, characterization and biological activity of transition metal complexes with Schiff bases derived from 2-nitrobenzaldehyde with glycine and methionine
Singh, Bibhesh K.
Rajour, Hemant K.
Prakash, Anant
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 94 : 143 - 151
[49] Synthesis and antimicrobial activity of bis(imido) Schiff bases derived from thiosemicarbazide with some 2-hydroxyaldehydes and metal complexes
Yildiz, M
Dülger, B
Koyuncu, SY
Yapici, BM
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2004, 81 (01) : 7 - 12
[50] Synthesis Characterization and Biological Activity Study of New Schiff and Mannich Bases and Some Metal Complexes Derived from Isatin and Dithiooxamide
Abdulghani, Ahlam J.
Abbas, Nada M.
BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2011, 2011

← 1 2 3 4 5 →