In recent years, mechanoluminescence, as a unique luminescence phenomenon, exhibited huge potential applications and rapid development in stress detection, anti-counterfeiting, encryption, light sources and bio-imaging, etc. Recently, great efforts have been made on molecular aggregation science, molecular packing and intermolecular interaction in the solid state have been deeply understood, directly promoting the development and application of mechanoluminescence and photoluminescence materials. The phenomenon and mechanism of mechanoluminescence were firstly introduced, the relationship between mechanoluminescence and aggregation behaviors of organic compounds were discussed in detail. The measurement and characterization of mechanoluminescence, the relationship between applied stress and mechanoluminescence intensity, and the color of mechanoluminescence were briefly introduced, then, the current application of mechanoluminescence was highlighted. In the end, the prospect of organic mechanoluminescence materials was afforded.