Light controlled drug delivery containers based on spiropyran doped liquid crystal micro spheres

被引：13
|
作者：
Petriashvili, Gia [1 ]
Devadze, Lali [1 ]
Zurabishvili, Tsisana [1 ]
Sepashvili, Nino [1 ]
Chubinidze, Ketevan [2 ]
机构：
[1] Georgian Tech Univ, Inst Cybernet, GE-0175 Tbilisi, Georgia
[2] Ivane Javakhishvili Tbilisi State Univ, 1 Ilia Chavchavadze Ave, GE-0179 Tbilisi, Georgia
来源：
BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 02期
基金：
美国国家科学基金会;
关键词：
RELEASE;
D O I：
10.1364/BOE.7.000442
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed a novel, light activated drug delivery containers, based on spiropyran doped liquid crystal micro spheres. Upon exposure to UV/violet light, the spiropyran molecules entrapped inside the nematic liquid crystal micro spheres, interconvert from the hydrophobic, oil soluble form, to the hydrophilic, water soluble merocyanine one, which stimulates the translocation of the merocyanine molecules across the nematic liquid crystal-water barrier and results their homogeneous distribution throughout in an aqueous environment. Light controllable switching property and extremely high solubility of spiropyran in the nematic liquid crystal, promise to elaborate a novel and reliable vehicles for the drug delivery systems. (C) 2016 Optical Society of America
引用
收藏
页码：442 / 447
页数：6
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