Synthesis of a Neonicotinoid Pesticide Derivative via Chemoenzymatic Dynamic Kinetic Resolution

被引：20
|
作者：
Krumlinde, Patrik [1 ]
Bogar, Krisztian [2 ]
Backvall, Jan-E [1 ]
机构：
[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden
[2] AstraZeneca R&D Sodertalje, Med Chem, Discovery, SE-15185 Sodertalje, Sweden
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 19期
基金：
瑞典研究理事会;
关键词：
SECONDARY ALCOHOLS; INSECTICIDE;
D O I：
10.1021/jo9014276
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chemoenzymatic dynamic kinetic resolution (DKR) via combined ruthenium and enzyme catalysis was used in the key step of a synthesis of a neonicotinoid pesticide derivative (S)-3. The DKR was carried Out under mild conditions with low catalyst loading. The method gives (S)-3 in high enantiomeric excess (98%).
引用
收藏
页码：7407 / 7410
页数：4
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