Exosomes from adipose-derived stem cells alleviate neural injury caused by microglia activation via suppressing NF-kB and MAPK pathway

被引：52
|
作者：
Feng, Nianhua [1 ]
Jia, Yanjun [1 ]
Huang, Xiaoxi [1 ]
机构：
[1] Capital Med Univ, Beijing Chaoyang Hosp, Med Res Ctr, 8 Gongti South St, Beijing 100020, Peoples R China
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 334卷
关键词：
Exosomes; Adipose-derived stem cells; Microglia; Inflammation; Neural injury; EXTRACELLULAR VESICLES; BRAIN-INJURY; INFLAMMATION; NEURODEGENERATION; TRANSPLANTATION; MICROVESICLES; NEUROGENESIS; EXPRESSION; CYTOKINES; PROMOTES;
D O I：
10.1016/j.jneuroim.2019.576996
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Activation of microglia cells play critical role in neuroinflammation after brain injury. Exosomes from adipose derived stem cells (ADSC) possess immunoregulation effect similar with ADSC. We hypothesized that ADSC derived exosomes (ADSC-exosomes) could inhibit the activation of microglia cells and prevent neuroinflammation. We found that ADSC-exosomes could inhibit the activation of microglia cells by suppressing NF-kB and MAPK pathway. Production of inflammatory factors in lipopolysaccharide-stimulated microglia cells decreased significantly when pretreated with ADSC-exosomes. Furthermore, ADSC-exosomes could decrease the cytotoxicity of activated microglia. These results revealed that ADSC-exosomes might be a promising strategy for the therapy of neural injury.
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页数：9
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