Iridium-catalyzed regio- and enantioselective allylic alkylation of fluorobis(phenylsulfonyl)methane

被引：70
|
作者：
Liu, Wen-Bo [2 ]
Zheng, Sheng-Cai [1 ]
He, Hu [2 ]
Zhao, Xiao-Ming [1 ]
Dai, Li-Xin [2 ]
You, Shu-Li [2 ]
机构：
[1] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2009年 / 43期
关键词：
ASYMMETRIC FLUORINATION; STEREOSELECTIVE MONOFLUOROMETHYLATION; NUCLEOPHILIC TRIFLUOROMETHYLATION; ALLYLATION REACTION; PERFLUOROALKYLATION; FLUOROALKYLATION; DERIVATIVES; SULFONES;
D O I：
10.1039/b914315g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly regio- and enantioselective allylic alkylation of fluorobis(phenylsulfonyl) methane (FBSM) has been realized by [Ir(COD)Cl](2)/phosphoramidite, affording enantiopure fluorobis(phenylsulfonyl)methylated compounds bearing a terminal alkene, which could be converted to monofluoro-methylated ibuprofen in just two steps without loss of the optical purity (95% ee).
引用
收藏
页码：6604 / 6606
页数：3
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