Iridium-catalyzed regio- and enantioselective allylic alkylation of fluorobis(phenylsulfonyl)methane

被引：70

作者：

Liu, Wen-Bo ^{[2
]}

Zheng, Sheng-Cai ^{[1
]}

He, Hu ^{[2
]}

Zhao, Xiao-Ming ^{[1
]}

Dai, Li-Xin ^{[2
]}

You, Shu-Li ^{[2
]}

机构：

[1] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 43期

关键词：

ASYMMETRIC FLUORINATION; STEREOSELECTIVE MONOFLUOROMETHYLATION; NUCLEOPHILIC TRIFLUOROMETHYLATION; ALLYLATION REACTION; PERFLUOROALKYLATION; FLUOROALKYLATION; DERIVATIVES; SULFONES;

D O I：

10.1039/b914315g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly regio- and enantioselective allylic alkylation of fluorobis(phenylsulfonyl) methane (FBSM) has been realized by [Ir(COD)Cl](2)/phosphoramidite, affording enantiopure fluorobis(phenylsulfonyl)methylated compounds bearing a terminal alkene, which could be converted to monofluoro-methylated ibuprofen in just two steps without loss of the optical purity (95% ee).

引用

页码：6604 / 6606

页数：3

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