Enantiomeric separation of diuretics on a novel pirkle-type chiral stationary phase

被引：3
|
作者：
Vercauteren, A
Van der Weken, G
Vankeirsbilck, T
Aboul-Enein, HY
Baeyens, WRG
机构：
[1] Ghent Univ, Dept Pharmaceut Anal, Lab Drug Anal, B-9000 Ghent, Belgium
[2] King Faisal Specialist Hosp & Res Ctr, Pharmaeut Anal Lab Biol & Med Res, Riyadh 11211, Saudi Arabia
来源：
BIOMEDICAL CHROMATOGRAPHY | 2002年 / 16卷 / 07期
关键词：
D O I：
10.1002/bmc.179
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A newly developed Pirkle-type straight chiral stationary phase (CSP), based on the 3,5-dinitrobenzoyl derivative of 1,2 diphenylethylene-diamine and known as ULMO, has been successfully applied to the direct resolution of the enantiomers of several diuretics by liquid chromatography. In this study, the effect of changes in the mobile phase and the intrinsic stereoselective properties of this CSP towards a specific racemate are determined experimentally. A mobile phase consisting of n-hexane and 2-propanol appears most appropriate for the chiral separation of the tested diuretics on the ULMO-column. Copyright (C) 2002 John Wiley Sons, Ltd.
引用
收藏
页码：437 / 440
页数：4
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