Directionality of kinesin motors

被引：0
|
作者：
Kasprzak, AA [1 ]
Hajdo, L [1 ]
机构：
[1] M Nencki Inst Expt Biol, Dept Muscle Biochem, PL-02093 Warsaw, Poland
来源：
ACTA BIOCHIMICA POLONICA | 2002年 / 49卷 / 04期
关键词：
molecular motor; kinesin; ncd; microtubule; force-generation; movement; ATP; mutation; X-ray crystallography;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Kinesins are molecular motors that transport various cargoes along microtubule tracks using energy derived from ATP hydrolysis. Although the motor domains of kinesins are structurally similar, the family contains members that move on microtubules in opposite directions. Recent biochemical and biophysical studies of several kinesins make it possible to identify structural elements responsible for the different directionality, suggesting that reversal of the motor movement can be achieved through small, local changes in the protein structure.
引用
收藏
页码：813 / 821
页数：9
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