Determination of beta-blocker drugs in pharmaceutical preparations by non-suppressed ion chromatography

被引：19
|
作者：
Ghanem, R [1 ]
Bello, MA [1 ]
Callejon, M [1 ]
Guiraum, A [1 ]
机构：
[1] UNIV SEVILLE,FAC CHEM,DEPT ANALYT CHEM,E-41012 SEVILLE,SPAIN
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1996年 / 15卷 / 03期
关键词：
beta-blockers; ion chromatography; pharmaceutical preparations;
D O I：
10.1016/S0731-7085(96)01864-X
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A rapid and feasible chromatographic method for determining atenolol, metoprolol, alprenolol, oxprenolol, acebutolol and propranolol by non-suppressed ion chromatography is proposed. The mobile phase consisted of 50 mM nitric acid in an aqueous Solution of 4% (v/v) acetonitrile. Detection limits are in the range 0.1-2.7 mg 1(-1). The method was successfully applied to the determination of beta-blockers in several pharmaceutical formulations.
引用
收藏
页码：383 / 388
页数：6
相关论文
共 50 条
  • [41] DETERMINATION OF CARBOXYLIC-ACIDS BY ION-EXCLUSION CHROMATOGRAPHY WITH NON-SUPPRESSED CONDUCTIVITY AND OPTICAL-DETECTORS
    YE, M
    HILL, K
    WALKUP, R
    CHROMATOGRAPHIA, 1993, 35 (3-4) : 139 - 141
  • [42] COMPARATIVE STUDY OF SUPPRESSED AND NON-SUPPRESSED ION-CHROMATOGRAPHY FOR SEPARATION OF ALKALINE EARTH IONS.
    Hajos, Peter
    Kecskemeti, Tamas
    Inczedy, Janos
    Reactive polymers. Ion exchangers, sorbents, 1986, 7 (2-3): : 239 - 245
  • [43] Simultaneous Determination of Nitrate and Nitrite in Saliva and Foodstuffs by Non-suppressed Ion Chromatography with Bulk Acoustic Wave Detector
    Bing-Sheng Yu
    Po Chen
    Li-Hua Nie
    Shou-Zhuo Yao
    Analytical Sciences, 2001, 17 : 495 - 498
  • [44] Determination of anticonvulsant drugs in pharmaceutical preparations by micellar liquid chromatography
    Cholbi-Cholbi, MF
    Martínez-Pla, JJ
    Sagrado, S
    Villanueva-Camañas, RM
    Medina-Hernández, MJ
    JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2004, 27 (01) : 153 - 170
  • [45] Optimization of a mobile phase for monitoring strontium in seawater using non-suppressed ion chromatography
    Butt, SB
    Farhat, W
    Jan, S
    Ahmed, S
    Mohammad, B
    Akram, N
    JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2004, 27 (11) : 1729 - 1742
  • [46] USE OF BETA-DIKETONATE ANIONS AS ELUENT IN NON-SUPPRESSED ION CHROMATOGRAPHY - ACETYLACETONATE ELUENT FOR THE SEPARATION OF FLUORIDE AND CHLORIDE
    HIRAYAMA, N
    MARUO, M
    SHIOTA, A
    KUWAMOTO, T
    JOURNAL OF CHROMATOGRAPHY, 1990, 523 : 257 - 264
  • [47] ANALYSIS OF FLUOROBORIC ACID IN CHROMIC-ACID SOLUTIONS BY NON-SUPPRESSED ION CHROMATOGRAPHY
    ANDREW, BE
    JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY & CHROMATOGRAPHY COMMUNICATIONS, 1987, 10 (04): : 211 - 212
  • [48] SENSITIVITY OF NON-SUPPRESSED ION CHROMATOGRAPHY USING DIVALENT ORGANIC-ACIDS AS ELUENTS
    OKADA, T
    KUWAMOTO, T
    JOURNAL OF CHROMATOGRAPHY, 1984, 284 (01): : 149 - 156
  • [49] DETERMINATION OF DEGRADED ETHANOLAMINES FOR POST-COMBUSTION CO2 CAPTURE TECHNOLOGY BY NON-SUPPRESSED ION CHROMATOGRAPHY
    Wang, Tielin
    Lopez, Miguel A. M.
    Hagen, Svein T.
    Jens, Klaus J.
    FRESENIUS ENVIRONMENTAL BULLETIN, 2012, 21 (8A): : 2298 - 2303
  • [50] COMPARATIVE-STUDY OF SUPPRESSED AND NON-SUPPRESSED ION-CHROMATOGRAPHY FOR SEPARATION OF ALKALINE-EARTH IONS
    HAJOS, P
    KECSKEMETI, T
    INCZEDY, J
    REACTIVE POLYMERS, 1988, 7 (2-3): : 239 - 245
12345