Determination of beta-blocker drugs in pharmaceutical preparations by non-suppressed ion chromatography

被引：19
|
作者：
Ghanem, R [1 ]
Bello, MA [1 ]
Callejon, M [1 ]
Guiraum, A [1 ]
机构：
[1] UNIV SEVILLE,FAC CHEM,DEPT ANALYT CHEM,E-41012 SEVILLE,SPAIN
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1996年 / 15卷 / 03期
关键词：
beta-blockers; ion chromatography; pharmaceutical preparations;
D O I：
10.1016/S0731-7085(96)01864-X
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A rapid and feasible chromatographic method for determining atenolol, metoprolol, alprenolol, oxprenolol, acebutolol and propranolol by non-suppressed ion chromatography is proposed. The mobile phase consisted of 50 mM nitric acid in an aqueous Solution of 4% (v/v) acetonitrile. Detection limits are in the range 0.1-2.7 mg 1(-1). The method was successfully applied to the determination of beta-blockers in several pharmaceutical formulations.
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页码：383 / 388
页数：6
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