[18F]MPPF as a tool fot the in vivo imaging of 5-HT1A receptors in animal and human brain

被引:74
|
作者
Aznavour, Nicolas
Zimmer, Luc
机构
[1] Univ Lyon 1, Lab Neuropharmacol, F-69365 Lyon, France
[2] CERMEP, Lyon, France
关键词
PET; serotonin; brain imaging; 5-HT1A receptors; MPPF;
D O I
10.1016/j.neuropharm.2006.09.023
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Serotonin (5-hydroxytryptamine, 5-HT) and its various receptors are involved in numerous CNS functions and psychiatric disorders. 5-HT1A, the best-characterized subtype of currently known 5-HT receptors, is tightly implicated in the pathogenesis of depression, anxiety, epilepsy and eating disorders. It thus represents an important target for drug therapy. Specific radioligands and positron emission tomography (PET) allow for a quantitative imaging of brain 5-HT1A receptor distribution in living animals and humans. Recently, the selective 5-HT1A receptor antagonist, MPPF, has been successfully labeled with [F-18]fluorine ([F-18]MPPF), and an increasing number of academic and industry centres have used this radiotracer in preclinical and clinical studies. After a brief account of some of the structural, distributional and electrophysiological characteristics of brain 5-HT1A receptors, this review focuses on studies conducted with [F-18]MPPF, with emphasis on preclinical results illustrating the actual and potential value of this PET radioligand for clinical research and drug development. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:695 / 707
页数:13
相关论文
共 50 条
  • [21] 5-HT1A gene promoter polymorphism and [18F]MPPF binding potential in healthy subjects: a PET study
    Lothe, Amelie
    Boni, Claudette
    Costes, Nicolas
    Bouvard, Sandrine
    Gorwood, Philip
    Lavenne, Franck
    Alvarez, Marion
    Ryvlin, Philippe
    BEHAVIORAL AND BRAIN FUNCTIONS, 2010, 6
  • [22] 5-HT1A gene promoter polymorphism and [18F]MPPF binding potential in healthy subjects: a PET study
    Amélie Lothe
    Claudette Boni
    Nicolas Costes
    Sandrine Bouvard
    Philip Gorwood
    Franck Lavenne
    Marion Alvarez
    Philippe Ryvlin
    Behavioral and Brain Functions, 6
  • [23] Quantitative assessment of 5-HT1A receptor occupancy with [18F]MPPF after treatment with pindolol or buspirone.
    Passchier, J
    Van Waarde, A
    Pieterman, RM
    Willemsen, AT
    Hendrikse, NH
    Pruim, J
    Vaalburg, W
    JOURNAL OF NUCLEAR MEDICINE, 2000, 41 (05) : 66P - 66P
  • [24] p-[F-18]-MPPF: A potential radioligand for PET studies of 5-HT1A receptors in humans
    Shiue, CY
    Shiue, GG
    Mozley, PD
    Kung, MP
    Zhuang, ZP
    Kim, HJ
    Kung, HF
    SYNAPSE, 1997, 25 (02) : 147 - 154
  • [25] [18F]F13640: a selective agonist PET radiopharmaceutical for imaging functional 5-HT1A receptors in humans
    Courault, Pierre
    Lancelot, Sophie
    Costes, Nicolas
    Colom, Matthieu
    Le Bars, Didier
    Redoute, Jerome
    Gobert, Florent
    Dailler, Frederic
    Isal, Sibel
    Iecker, Thibaut
    Newman-Tancredi, Adrian
    Merida, Ines
    Zimmer, Luc
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 50 (06) : 1651 - 1664
  • [26] [18F]F13640: a selective agonist PET radiopharmaceutical for imaging functional 5-HT1A receptors in humans
    Pierre Courault
    Sophie Lancelot
    Nicolas Costes
    Matthieu Colom
    Didier Le Bars
    Jérôme Redoute
    Florent Gobert
    Frédéric Dailler
    Sibel Isal
    Thibaut Iecker
    Adrian Newman-Tancredi
    Inés Merida
    Luc Zimmer
    European Journal of Nuclear Medicine and Molecular Imaging, 2023, 50 : 1651 - 1664
  • [27] Acute and Chronic Effects of Citalopram on 5-HT1A Receptor-Labeling by [18F]MPPF and-Coupling to Receptors-G Proteins
    Moulin-Sallanon, Marcelle
    Charnay, Yves
    Ginovart, Nathalie
    Perret, Pascale
    Lanfumey, Laurence
    Hamon, Michel
    Hen, Rene
    Fagret, Daniel
    Ibanez, Vicente
    Millet, Philippe
    SYNAPSE, 2009, 63 (02) : 106 - 116
  • [28] Quantification of 5-HT1A receptors in human brain using p-MPPF kinetic modelling and PET
    Sanabria-Bohórquez, SM
    Biver, F
    Damhaut, P
    Wikler, D
    Veraart, C
    Goldman, S
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 2002, 29 (01) : 76 - 81
  • [29] Brain5-HT1AReceptor Binding in Multiple System Atrophy: An [18F]-MPPF PETStudy
    Meyer, Marie
    Lamare, Frederic
    Asselineau, Julien
    Foubert-Samier, Alexandra
    Mazere, Joachim
    Zanotti-Fregonara, Paolo
    Rizzo, Gaia
    Delamarre, Anna
    Spampinato, Umberto
    Rascol, Olivier
    Pavy-Le Traon, Anne
    Tison, Francois
    Fernandez, Philippe
    Sibon, Igor
    Meissner, Wassilios G.
    MOVEMENT DISORDERS, 2021, 36 (01) : 246 - 251
  • [30] Initial in vivo PET imaging of 5-HT1A receptors with 3-[F-18]mefway
    Wooten, Dustin W.
    Hillmer, Ansel T.
    Murali, Dhanabalan
    Barnhart, Todd E.
    Thio, Joanne P.
    Bajwa, Alisha K.
    Bonab, Ali A.
    Normandin, Marc D.
    Schneider, Mary L.
    Mukherjee, Jogeshwar
    Christian, Bradley T.
    AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 4 (05):