Cognitive Impairment and Dementia in Patients with Parkinson Disease

被引：0

作者：

Leverenz, James B. ^{[2
,3
,4
,6
]}

Quinn, Joseph F. ^{[6
,7
]}

Zabetian, Cyrus ^{[2
,5
,6
]}

Zhang, Jing ^{[1
]}

Montine, Kathleen S. ^{[1
]}

Montine, Thomas J. ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98104 USA

[2] Univ Washington, Dept Neurol, Seattle, WA 98104 USA

[3] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98104 USA

[4] Oregon Hlth & Sci Univ, Mental Illness Res Educ & Clin Ctr, Vet Adm, Portland, OR 97201 USA

[5] Oregon Hlth & Sci Univ, Geriatr Res Educ & Clin Ctr, Vet Adm, Portland, OR 97201 USA

[6] Oregon Hlth & Sci Univ, Parkinson Dis Res Educ & Clin Ctr, Vet Adm, Portland, OR 97201 USA

[7] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 10期

关键词：

Parkinson disease; cognitive impairment; dementia; Alzheimer disease; Demenita with Lewy bodies; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBROSPINAL-FLUID LEVELS; MEDIUM SPINY NEURONS; LEWY BODY DISEASE; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; GLUCOCEREBROSIDASE GENE; CLINICAL-DIAGNOSIS; RISK-FACTOR; DENDRITIC DEGENERATION;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Parkinson disease (PD) is an already prevalent neurodegenerative disease that is poised to at least double over the next 25 years. Although best known for its characteristic movement disorder, PD is now appreciated commonly to cause cognitive impairment, including dementia, and behavioral changes. Dementia in patients with PD is consequential and has been associated with reduced quality of life, shortened survival, and increased caregiver distress. Here we review clinical presentation and progression, pathological bases, identification of genetic risk factors, development of small molecule biomarkers, and emerging treatments for cognitive impairment in patients with PD.

引用

页码：903 / 912

页数：10

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