Cognitive Impairment and Dementia in Parkinson's Disease

被引：24

作者：

Marder, Karen ^{[1
,2
,3
,4
]}

机构：

[1] Columbia Univ, Dept Neurol, New York, NY USA

[2] Columbia Univ, Dept Psychiat, New York, NY USA

[3] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY USA

[4] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA

来源：

MOVEMENT DISORDERS | 2010年 / 25卷 / 03期

关键词：

Parkinson's disease; dementia; cognitive impairment; DEEP BRAIN-STIMULATION; LRRK2 G2019S MUTATION; EPSILON; 4; ALLELE; APOLIPOPROTEIN-E; RISK-FACTORS; ALPHA-SYNUCLEIN; GLUCOCEREBROSIDASE MUTATIONS; FAMILIAL AGGREGATION; SUBTHALAMIC NUCLEUS; ALZHEIMERS-DISEASE;

D O I：

10.1002/mds.22787

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Over the last decade, the importance of cognitive impairment and dementia in Parkinson's disease (PDD) has been increasingly recognized. Investigators have proposed criteria for PD dementia, and mild cognitive impairment. Risk profiles associated with the development of dementia based on demographic, neurological, neuropsychological, imaging, and genetic investigations have been delineated. The FDA has approved a treatment for PDD, and efforts now are directed toward intervention at earlier stages of cognitive impairment. (C) 2010 Movement Disorder Society

引用

页码：S110 / S116

页数：7

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