A novel translocation (17;19)(p13;p13) in a patient with acute myelomonocytic leukemia

被引：5
|
作者：
Brückner, R
Jentsch-Ullrich, K
Franke, A
Wieacker, P
Stumm, M
机构：
[1] Univ Hosp Magdeburg, Dept Human Genet, Magdeburg, Germany
[2] Univ Hosp Magdeburg, Dept Hematol & Oncol, Magdeburg, Germany
来源：
CANCER GENETICS AND CYTOGENETICS | 2000年 / 119卷 / 01期
关键词：
D O I：
10.1016/S0165-4608(99)00214-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report on a patient with acute myeloid leukemia (AML M4) and a so far unrecorded translocation (17;19). The leukemia transformed from a myeloproliferative disorder (MPD) and showed ct progressive fatal course. Following transformation, all leukemic cells showed an apparently balanced translocation (17;19)(p13;p13). The breakpoint regions harbor genes such as TP53 (17p13) and E2A, ENL, or LYL1 (19p13), which could be relevant in leukemogenesis. We suspect that the translocation (17;19) (p13;p13) may be a prognostic factor for transformation from chronic MPD to acute leukemia. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：77 / 79
页数：3
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