A novel translocation (17;19)(p13;p13) in a patient with acute myelomonocytic leukemia

被引：5
|
作者：
Brückner, R
Jentsch-Ullrich, K
Franke, A
Wieacker, P
Stumm, M
机构：
[1] Univ Hosp Magdeburg, Dept Human Genet, Magdeburg, Germany
[2] Univ Hosp Magdeburg, Dept Hematol & Oncol, Magdeburg, Germany
来源：
CANCER GENETICS AND CYTOGENETICS | 2000年 / 119卷 / 01期
关键词：
D O I：
10.1016/S0165-4608(99)00214-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report on a patient with acute myeloid leukemia (AML M4) and a so far unrecorded translocation (17;19). The leukemia transformed from a myeloproliferative disorder (MPD) and showed ct progressive fatal course. Following transformation, all leukemic cells showed an apparently balanced translocation (17;19)(p13;p13). The breakpoint regions harbor genes such as TP53 (17p13) and E2A, ENL, or LYL1 (19p13), which could be relevant in leukemogenesis. We suspect that the translocation (17;19) (p13;p13) may be a prognostic factor for transformation from chronic MPD to acute leukemia. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：77 / 79
页数：3
相关论文
共 50 条
  • [1] t(9;19)(q22;p13) in Acute Myelomonocytic Leukemia
    Safavi, Moeinadin
    Safaei, Akbar
    Hosseini, Marzieh
    TURKISH JOURNAL OF HEMATOLOGY, 2018, 35 (01) : 89 - 90
  • [2] A novel t(3;19)(p21;p13) in a patient with acute myelocytic leukemia
    Zhai, Zhimin
    Ding, Kaiyang
    Wu, Guolin
    CANCER GENETICS AND CYTOGENETICS, 2007, 179 (02) : 165 - 166
  • [3] Translocation (12;15)(p13;q13) in a patient with relapsed acute myeloid leukemia
    Lim, SW
    Falk, RE
    Look, RM
    Fuerst, MM
    Lawrence, GN
    Kusuanco, DA
    Giles, FJ
    CANCER GENETICS AND CYTOGENETICS, 1996, 86 (02) : 165 - 167
  • [4] A novel translocation, t(3;20)(q13;p13), in acute monocytic leukemia
    Qian, Bin
    Sun, Zimin
    Wu, Zhiwei
    Liu, Huilan
    Wang, Xingbing
    Zhai, Zhimin
    CANCER GENETICS AND CYTOGENETICS, 2009, 188 (01) : 52 - 53
  • [5] Dicentric (19;21)(p13;p13), a novel chromosomal abnormality occurring in a case of Philadelphia chromosome-positive acute lymphoblastic leukemia
    Schilling, G
    Dierlamm, J
    Penas, EMM
    Hinz, K
    Seeger, D
    Hossfeld, DK
    CANCER GENETICS AND CYTOGENETICS, 2004, 152 (02) : 129 - 131
  • [6] A novel translocation t(8;10)(q12;p13) in acute myeloid leukemia
    Talavera Yaguez, M.
    Ferro, M. T.
    Villalon, C.
    de Leon, A.
    Garcia-Sagredo, J. A.
    Garcia Miguel, P.
    Polo, M.
    San Roman, C.
    CHROMOSOME RESEARCH, 2007, 15 : 204 - 205
  • [7] A novel recurrent translocation t(7;17)(q22;p13) and a late-appearing t(2;3)(p13;q26.2) with dysmegakaryopoiesis in acute myeloid leukemia
    Yamamoto, Katsuya
    Okamura, Atsuo
    Inui, Yumiko
    Yakushijin, Kimikazu
    Matsuoka, Hiroshi
    Minami, Hironobu
    LEUKEMIA RESEARCH, 2012, 36 (04) : E84 - E86
  • [8] Translocation (8;12)(q13;p13)during disease progression in acute myelomonocytic leukemia with t(11;19)(q23;p13.1)
    Yamamoto, K
    Nagata, K
    Tsurukubo, Y
    Inagaki, K
    Ono, R
    Taki, T
    Hayashi, Y
    Hamaguchi, H
    CANCER GENETICS AND CYTOGENETICS, 2002, 137 (01) : 64 - 67
  • [9] Transient acute monoblastic leukemia with reciprocal (8;16)(p11;p13) translocation
    Heim, S
    PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1996, 13 (03) : 203 - 204
  • [10] Translocation (X;12)(p11;p13) as a sole abnormality in biphenotypic acute leukemia
    Manola, Kalliopi N.
    Georgakakos, Vasileios N.
    Marinakis, Theodore
    Stavropoulou, Chryssa
    Paterakis, George
    Anagnostopoulos, Nikolaos I.
    Pantelias, Gabriel E.
    Sambani, Constantina
    CANCER GENETICS AND CYTOGENETICS, 2007, 173 (02) : 159 - 163
12345