Priority directions in the design of biologically active compounds based on 2-aminopyrimidin-4(3H)-one and its derivatives

被引：0
|
作者：
Erkin, Andrei V. [1 ]
Krutikov, Viktor I. [1 ]
Garabadzhiu, Alexander V. [1 ]
机构：
[1] Tech Univ, St Petersburg State Inst Technol, 26 Moskovsky Ave, St Petersburg 190013, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2021年 / 57卷 / 02期
关键词：
2-amino-6-arylpyrimidin-4(3H)-ones; 2-amino-3-methyl-5,6-dihydropyrimidin-4(3H)-ones; imidazo[1,2-a]pyrimidines; meridianins; nucleosides; biological activity; cyclocondensation; Heck reaction; Suzuki reaction;
D O I：
10.1007/s10593-021-02875-w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This review compiles literature data on the design of biologically active compounds based on 2-aminopyrimidin-4(3H)-one and its derivatives over the past 20 years. The systematization and analysis of the collected data made it possible to identify the priority directions of this process, including the development of antiviral and antileukemic agents, drugs for combating hyperuricemia, neurodegenerative disorders, some forms of cancer and, finally, anti-inflammatory and hormonal drugs.
引用
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页码：103 / 121
页数：19
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