Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia

被引:26
|
作者
Scotto, Riccardo [1 ]
Pinchera, Biagio [1 ]
Perna, Francesco [2 ]
Atripaldi, Lidia [3 ]
Giaccone, Agnese [1 ]
Sequino, Davide [2 ]
Zappulo, Emanuela [1 ]
Sardanelli, Alessia [1 ]
Schiano Moriello, Nicola [1 ]
Stanziola, Anna [2 ]
Bocchino, Marialuisa [2 ]
Gentile, Ivan [1 ,4 ]
Sanduzzi, Alessandro [2 ,4 ]
机构
[1] Univ Naples Federico II, Dept Clin Med & Surg, Infect Dis Sect, I-80131 Naples, Italy
[2] Univ Naples Federico II, Sect Resp Dis, Dept Clin Med & Surg, Monaldi Hosp, I-80131 Naples, Italy
[3] Monaldi Hosp, Lab Clin Biochem, I-80131 Naples, Italy
[4] Univ Federico II Naples, United Nations Educ Sci & Cultural Org UNESCO, Hlth Educ & Sustainable Dev, I-80131 Naples, Italy
关键词
COVID-19; SARS-CoV-2; KL-6; pneumonia; mortality; EPITHELIAL LINING FLUID; MUCIN-LIKE GLYCOPROTEIN; PROGNOSTIC VALUE; ACUTE EXACERBATION; PULMONARY; MARKER; PLASMA;
D O I
10.3390/ijerph18042078
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
KL-6 is a sialoglycoprotein antigen which proved elevated in the serum of patients with different interstitial lung diseases, especially in those with a poorer outcome. Given that interstitial pneumonia is the most common presentation of SARS-CoV2 infection, we evaluated the prognostic role of KL-6 in patients with COVID-19 pneumonia. Patients with COVID-19 pneumonia were prospectively enrolled. Blood samples were collected at the time of enrolment (TOE) and on day 7 (T1). Serum KL-6 concentrations were measured by chemiluminescence enzyme immunoassay using a KL-6 antibody kit (LUMIPULSE G1200, Fujirebio) and the cut-off value was set at >1000 U/mL. Fifteen out of 34 enrolled patients (44.1%) died. Patients with unfavourable outcome showed significantly lower P/F ratio and higher IL-6 values and plasmatic concentrations of KL-6 at TOE compared with those who survived (median KL-6: 1188 U/mL vs. 260 U/mL, p < 0.001). KL-6 > 1000 U/mL resulted independently associated with death (aOR: 11.29, p < 0.05) with a positive predictive value of 83.3%. Our results suggest that KL-6 is a reliable indicator of pulmonary function and unfavourable outcome in patients with COVID-19 pneumonia. A KL-6 value > 1000 U/mL resulted independently associated with death and showed good accuracy in predicting a poorer outcome. KL-6 may thus represent a quick, inexpensive, and sensitive parameter to stratify the risk of severe respiratory failure and death.
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页码:1 / 11
页数:10
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