A flexible synthesis of novel homoharringtonine ester chain

被引：2

作者：

Thi Hong Nhung Nguyen ^{[1
]}

Thai Thanh Thu Bui ^{[1
]}

Phong Van Pham ^{[2
]}

Dinh Hung Mac ^{[1
]}

机构：

[1] VNU Univ Sci, Med Chem Lab, Fac Chem, 19 Le Thanh Tong, Hanoi, Vietnam

[2] VNU Univ Sci, Catalysis Lab, Fac Chem, 19 Le Thanh Tong, Hanoi, Vietnam

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 02期

关键词：

Mizoroki-Heck reaction; Boronic acids; Homoharringtonine; D-Malic acid; HECK TYPE REACTION; ALKALOIDS; BOND;

D O I：

10.1016/j.tetlet.2015.12.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New homoharringtonine ester chains bearing aryl substituents were obtained using a flexible synthesis. D-Malic acid was utilized to achieve the diastereoselective allylation at the C2' center. A key oxidative Mizoroki-Heck reaction allowed the coupling of various phenyl boronic acids with the allyl intermediate to provide arylated products in excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：216 / 218

页数：3

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