A flexible synthesis of novel homoharringtonine ester chain

被引：2
|
作者：
Thi Hong Nhung Nguyen [1 ]
Thai Thanh Thu Bui [1 ]
Phong Van Pham [2 ]
Dinh Hung Mac [1 ]
机构：
[1] VNU Univ Sci, Med Chem Lab, Fac Chem, 19 Le Thanh Tong, Hanoi, Vietnam
[2] VNU Univ Sci, Catalysis Lab, Fac Chem, 19 Le Thanh Tong, Hanoi, Vietnam
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 02期
关键词：
Mizoroki-Heck reaction; Boronic acids; Homoharringtonine; D-Malic acid; HECK TYPE REACTION; ALKALOIDS; BOND;
D O I：
10.1016/j.tetlet.2015.12.012
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New homoharringtonine ester chains bearing aryl substituents were obtained using a flexible synthesis. D-Malic acid was utilized to achieve the diastereoselective allylation at the C2' center. A key oxidative Mizoroki-Heck reaction allowed the coupling of various phenyl boronic acids with the allyl intermediate to provide arylated products in excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：216 / 218
页数：3
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