Challenges of antibacterial drug discovery

被引：8

作者：

Reck, Folkert ^{[1
]}

Jansen, Johanna M. ^{[1
]}

Moser, Heinz E. ^{[1
]}

机构：

[1] Novartis Inst BioMed Res, 5300 Chiron Way, Emeryville, CA 94608 USA

来源：

ARKIVOC | 2019年

关键词：

Drug discovery; antibiotics; property space; safety; medicinal chemistry; PERMEABILITY; SOLUBILITY; ACTIVATION; CHEMISTRY; MECHANISM; TRENDS; AGENTS; BROAD;

D O I：

10.24820/ark.5550190.p010.955

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efforts to discover novel antibacterial drugs over the past decades have been characterized by high attrition rates, driven mainly by technical challenges, high dose and safety requirements, regulatory difficulties and low-cost generic competition, resulting in a broken financial model. Consequently, most pharmaceutical and biotech companies have exited their research efforts in this field, leaving the required rejuvenation of antibacterial drugs under-resourced. This article sheds light on some of the technical difficulties and offers thoughts and suggestions on how to address and overcome these. [GRAPHICS] .

引用

页码：227 / 244

页数：18

共 50 条

[21] Antibacterial Drug Discovery: Doing It Right
Gengenbacher, Martin
Dick, Thomas
CHEMISTRY & BIOLOGY, 2015, 22 (01): : 5 - 6
[22] Challenges of allosterism in drug discovery
Christopoulos, A.
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2008, 22 : 28 - 28
[23] Challenges for Academic Drug Discovery
Jorgensen, William L.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (47) : 11680 - 11684
[24] Stability Challenges in Drug Discovery
Di, Li
Kerns, Edward H.
CHEMISTRY & BIODIVERSITY, 2009, 6 (11) : 1875 - 1886
[25] Challenges in antimalarial drug discovery
Burrows, Jeremy N.
Leroy, Didier
Lotharius, Julie
Waterson, David
FUTURE MEDICINAL CHEMISTRY, 2011, 3 (11) : 1401 - 1412
[26] Challenges in neurodegeneration drug discovery
Lu, Bai
AMINO ACIDS, 2011, 41 : S41 - S41
[27] Confronting the challenges of discovery of novel antibacterial agents
Singh, Sheo B.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (16) : 3683 - 3689
[28] Structural biology approaches to antibacterial drug discovery
Holler, Tod P.
Evdokimov, Artem G.
Narasimhan, Lakshmi
EXPERT OPINION ON DRUG DISCOVERY, 2007, 2 (08) : 1085 - 1101
[29] Why it is important to continue antibacterial drug discovery
Bush, K
ASM NEWS, 2004, 70 (06): : 282 - 287
[30] Antibacterial Drug Discovery: Some Assembly Required
Tommasi, Ruben
Iyer, Ramkumar
Miller, Alita A.
ACS INFECTIOUS DISEASES, 2018, 4 (05): : 686 - 695

← 1 2 3 4 5 →