Two new lignans from the fruits of Forsythia suspensa

被引：8
|
作者：
Cao, Jun [1 ,2 ]
Shao, Si-Yuan [1 ,2 ]
Zhang, Xu [1 ,2 ]
Yuan, Xiang [1 ,2 ]
Feng, Zi-Ming [1 ,2 ]
Jiang, Jian-Shuang [1 ,2 ]
Yang, Ya-Nan [1 ,2 ]
Zhang, Pei-Cheng [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Oleaceae; Forsythia suspensa; sesquinorlignan; PHENYLETHANOID GLYCOSIDES; EXTRACT;
D O I：
10.1080/10286020.2019.1666828
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new lignans, wikstronoside B (1) and forsysesquinorlignan (2), were isolated from the fruits of Forsythia suspensa, along with two known sesquineolignans, hedyotol A and hedyotol C (3 and 4). The structures of new compounds were established via extensive spectroscopy techniques, including UV, IR, HRESIMS, NMR, and ECD. Compounds 3 and 4 were isolated from this plant for the first time. Their anti-inflammatory effects were evaluated via a detection model with LPS-induced murine macrophage RAW264.7 cells, and compound 3 showed a moderate activity.
引用
收藏
页码：418 / 424
页数：7
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