Studies of the Asymmetric Total Synthesis of Clavilactone D by the 'Lariat' Cyclization Strategy

被引：11

作者：

Yoshimitsu, Takehiko ^{[1
]}

Nojima, Shoji ^{[1
]}

Hashimoto, Masashi ^{[1
]}

Tsukamoto, Koji ^{[1
]}

Tanaka, Tetsuaki ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

SYNTHESIS-STUTTGART | 2009年 / 17期

关键词：

total synthesis; natural products; cyclizations; asymmetric synthesis; alkylations; ORGANIC-SYNTHESIS; STRUCTURE ELUCIDATION; RADICAL REACTIONS; INDIUM METAL;

D O I：

10.1055/s-0029-1216909

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A route to the core structure of clavilactone D, a new member of the tyrosine kinase inhibitors, is reported. The route employs sequential cyclization initiated by iodo etherification followed by Friedel-Crafts cyclization to furnish a polycyclic lactone fused with an aromatic ring, which is readily transformed into the proposed clavilactone scaffold.

引用

页码：2963 / 2969

页数：7

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