Isolation of two novel genes, down-regulated in gastric cancer

被引：107

作者：

Yoshikawa, Y

Mukai, H

Hino, F

Asada, K

Kato, I

机构：

[1] Takara Shuzo Co Ltd, Adv Biomed Ctr, Shiga 525055, Japan

[2] Takara Shuzo Co Ltd, Biotechnol Res Labs, Otsu, Shiga 5202134, Japan

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 2000年 / 91卷 / 05期

关键词：

differential display; down-regulated expression; gastric cancer; digestive tract-specific calpain nCL-4;

D O I：

10.1111/j.1349-7006.2000.tb00967.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using a differential display technique, we identified two genes that are down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. The down-regulated expression of these genes in gastric cancer tissue was confirmed by northern blotting analysis and RT-PCR. One, CA11, was a novel gene expressed predominantly in the stomach and was depleted in all of the gastric cancer cell lines examined. The other gene, GC36, was homologous to the digestive tract-specific calpain gene, nCL-4, The expression of both GC36 and nCL-4 was suppressed or depleted in gastric cancer cell lines of differentiated and poorly differentiated types, This is the first report of genes, the expression of which is down-regulated with considerable frequency in gastric cancer.

引用

页码：459 / 463

页数：5

共 50 条

[41] Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK
Wang, Ming
Li, Chenglong
Nie, Hui
Lv, Xin
Qu, Ying
Yu, Beiqin
Su, Liping
Li, Jianfang
Chen, Xuehua
Ju, Jingfang
Yu, Yingyan
Yan, Min
Gu, Qinlong
Zhu, Zhenggang
Liu, Bingya
FEBS LETTERS, 2012, 586 (16) : 2382 - 2388
[42] Human stomach-specific gene, CA11, is down-regulated in gastric cancer
Shiozaki, K
Nakamori, S
Tsujie, M
Okami, J
Yamamoto, H
Nagano, H
Dono, K
Umeshita, K
Sakon, M
Furukawa, H
Hiratsuka, M
Kasugai, T
Ishiguro, S
Monden, M
INTERNATIONAL JOURNAL OF ONCOLOGY, 2001, 19 (04) : 701 - 707
[43] SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation
Lai, Rai-Hua
Hsiao, Ya-Wen
Wang, Mei-Jung
Lin, Huan-Yu
Wu, Chew-Wun
Chi, Chin-Wen
Li, Anna Fen-Yau
Jou, Yuh-Shan
Chen, Jeou-Yuan
CANCER LETTERS, 2010, 288 (01) : 75 - 85
[44] SOX7 is down-regulated in lung cancer
Takahide Hayano
Manoj Garg
Dong Yin
Makoto Sudo
Norihiko Kawamata
Shuo Shi
Wenwen Chien
Ling-wen Ding
Geraldine Leong
Seiichi Mori
Dong Xie
Patrick Tan
H Phillip Koeffler
Journal of Experimental & Clinical Cancer Research, 32
[45] SOX7 is down-regulated in lung cancer
Hayano, Takahide
Garg, Manoj
Yin, Dong
Sudo, Makoto
Kawamata, Norihiko
Shi, Shuo
Chien, Wenwen
Ding, Ling-wen
Leong, Geraldine
Mori, Seiichi
Xie, Dong
Tan, Patrick
Koeffler, H. Phillip
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2013, 32
[46] Identification of a novel gene, LDOC1, down-regulated in cancer cell lines
Nagasaki, K
Manabe, T
Hanzawa, H
Maass, N
Tsukada, T
Yamaguchi, K
CANCER LETTERS, 1999, 140 (1-2) : 227 - 234
[47] Detection of novel genes that are up-regulated (Di12) or down-regulated (T1A12) with disease progression in breast cancer
Burger, AM
Zhang, X
Seth, A
EUROPEAN JOURNAL OF CANCER PREVENTION, 1998, 7 : S29 - S35
[48] ISOLATION AND CHARACTERIZATION OF 3 FAMILIES OF AUXIN DOWN-REGULATED CDNA CLONES
DATTA, N
LAFAYETTE, PR
KRONER, PA
NAGAO, RT
KEY, JL
PLANT MOLECULAR BIOLOGY, 1993, 21 (05) : 859 - 869
[49] Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by β-catenin
Kawasoe, T
Furukawa, Y
Daigo, Y
Nishiwaki, T
Ishiguro, H
Fujita, M
Satoh, S
Miwa, N
Nagasawa, Y
Miyoshi, Y
Ogawa, M
Nakamura, Y
CANCER RESEARCH, 2000, 60 (13) : 3354 - 3358
[50] Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans
Honda, Yoko
Higashibata, Akira
Matsunaga, Yohei
Yonezawa, Yukiko
Kawano, Tsuyoshi
Higashitani, Atsushi
Kuriyama, Kana
Shimazu, Toru
Tanaka, Masashi
Szewczyk, Nathaniel J.
Ishioka, Noriaki
Honda, Shuji
SCIENTIFIC REPORTS, 2012, 2

← 1 2 3 4 5 →