Isolation of two novel genes, down-regulated in gastric cancer

被引：107
|
作者：
Yoshikawa, Y
Mukai, H
Hino, F
Asada, K
Kato, I
机构：
[1] Takara Shuzo Co Ltd, Adv Biomed Ctr, Shiga 525055, Japan
[2] Takara Shuzo Co Ltd, Biotechnol Res Labs, Otsu, Shiga 5202134, Japan
来源：
JAPANESE JOURNAL OF CANCER RESEARCH | 2000年 / 91卷 / 05期
关键词：
differential display; down-regulated expression; gastric cancer; digestive tract-specific calpain nCL-4;
D O I：
10.1111/j.1349-7006.2000.tb00967.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Using a differential display technique, we identified two genes that are down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. The down-regulated expression of these genes in gastric cancer tissue was confirmed by northern blotting analysis and RT-PCR. One, CA11, was a novel gene expressed predominantly in the stomach and was depleted in all of the gastric cancer cell lines examined. The other gene, GC36, was homologous to the digestive tract-specific calpain gene, nCL-4, The expression of both GC36 and nCL-4 was suppressed or depleted in gastric cancer cell lines of differentiated and poorly differentiated types, This is the first report of genes, the expression of which is down-regulated with considerable frequency in gastric cancer.
引用
收藏
页码：459 / 463
页数：5
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