Reaction of trimethylsilyl benzhydryl ethers with methyl N-(trimethylsilyl)pyroglutamate: An easy and rapid N-alkylation

被引：0
|
作者：
Rigo, B
Gautret, P
Legrand, A
Henichart, JP
Couturier, D
机构：
[1] FAC PHARM LILLE,INST CHIM PHARMACEUT,F-59006 LILLE,FRANCE
[2] UNIV SCI & TECHNOL LILLE,LAB CHIM ORGAN & ENVIRONM,F-59655 VILLENEUVE DASCQ,FRANCE
来源：
SYNLETT | 1997年 / 08期
关键词：
methyl N-(trimethylsilyl)pyroglutamate; benzhydryl silyl ethers; N-alkylation;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the presence of a small amount of catalyst (mainly triflic acid), methyl N-(trimethylsilyl)pyroglutamate quickly reacts with benzhydryl chlorides or preferentially with trimethylsilyl benzhydryl ethers to give methyl N-(benzhydryl)pyroglutamates in nearly quantitative isolated yields.
引用
收藏
页码：998 / &
页数：4
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