Pharmacogenetic prediction of clozapine response

被引：233
|
作者：
Arranz, MJ
Munro, J
Birkett, J
Bolonna, A
Mancama, D
Sodhi, M
Lesch, KP
Meyer, JFW
Sham, P
Collier, DA
Murray, RM
Kerwin, RW
机构：
[1] Inst Psychiat, Dept Clin Neurophysiol, London SE5 8AF, England
[2] Inst Psychiat, Dept Psychol Med, London SE5 8AF, England
[3] Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany
来源：
LANCET | 2000年 / 355卷 / 9215期
关键词：
D O I：
10.1016/S0140-6736(00)02221-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine In schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/-0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.
引用
收藏
页码：1615 / 1616
页数：2
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