Enhancement of signal-to-noise ratio for fluorescence endoscope image based on fast digital lock-in algorithm

被引:4
|
作者
Wang, Huiquan [1 ]
Hu, Meng [2 ]
Xia, Fang [1 ]
Guo, Meng [1 ]
Zhang, Shengzhao [3 ]
Zhao, Zhe [2 ]
Han, Guang [1 ]
Wang, Jinhai [1 ]
机构
[1] Tiangong Univ, Sch Life Sci, Tianjin 300387, Peoples R China
[2] Tiangong Univ, Sch Elect & Informat Engn, Tianjin 300387, Peoples R China
[3] Anhui Med Univ, Sch Biomed Engn, Hefei 230032, Peoples R China
来源
ROYAL SOCIETY OPEN SCIENCE | 2021年 / 8卷 / 03期
基金
中国国家自然科学基金;
关键词
fluorescence endoscope; tumour; fast digital lock-in algorithm; image SNR;
D O I
10.1098/rsos.200779
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this paper, the signal-to-noise ratios (SNR) of two image channels were enhanced with the fast digital lock-in algorithm. In order to simultaneously improve the quality of white and fluorescence images obtained by fluorescence endoscope, and improve the SNR to achieve a better image processing effect, two sources of white light and near-infrared light of a fluorescence endoscope were modulated, then the acquired images were demodulated into white and fluorescence images. A fluorescent endoscope experimental platform was setup to acquire endoscopic images of a target dyed by indocyanine green. The experimental results showed that the SNR of white and fluorescent images without the lock-in algorithm were 36.56 dB and 33.47 dB, respectively. However, with the lock-in algorithm, the SNR of white and fluorescent images were 39.54 dB and 35.70 dB, respectively. The SNR of white and fluorescent images was increased by 8.2% and 6.7%, respectively, by appling the digital lock-in algorithm. Therefore, this novel fluorescence endoscope based on the fast digital lock-in algorithm can rapidly and simultaneously obtain two-channel images of white light and fluorescence, effectively enhance the SNR of white and fluorescent images, and improve the imaging quality.
引用
收藏
页数:9
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