Copper-Catalyzed Diastereoselective 1,2-Difunctionalization of Oxabenzonorbornadienes Leading to β-Thiocyanato Thioethers

被引：21

作者：

Lin, Qifu ^{[1
,2
]}

Yang, Wen ^{[1
]}

Yao, Yongqi ^{[1
]}

Chen, Shuqi ^{[1
]}

Tan, Yun ^{[1
]}

Chen, Donghan ^{[1
]}

Yang, Dingqiao ^{[1
]}

机构：

[1] South China Normal Univ, Minist Educ, Coll Chem, Key Lab Theoret Chem Environm, Guangzhou 510006, Guangdong, Peoples R China

[2] Beibu Gulf Univ, Coll Marine Sci, Qinzhou 535011, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 18期

基金：

中国国家自然科学基金;

关键词：

RING-OPENING REACTIONS; C-H BOND; OXABICYCLIC ALKENES; OXA(AZA)BICYCLIC ALKENES; HETEROBICYCLIC ALKENES; AZABICYCLIC ALKENES; ARYL THIOCYANATES; SULFUR; WATER; SULFIDES;

D O I：

10.1021/acs.orglett.9b02452

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel copper-catalyzed complete diastereoselective 1,2-difunctionalization of oxabicyclic alkenes has been developed. Two C-S bonds were constructed simultaneously on the oxabenzonorbornadienes leading to beta-thiocyanato thioethers through the three-component (oxabicyclic alkenes, aryl iodides, and potassium thiocyanate), one-pot reaction. Various functional groups attached to the substrates were tolerated in this protocol to afford the corresponding beta-thiocyanato thioether products in moderate yields.

引用

页码：7244 / 7247

页数：4

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