Protective effects of essential oil of Citrus limon against aspirin-induced toxicity in IEC-6 cells

被引：9
|
作者：
Bouzenna, Hafsia [1 ,2 ,3 ]
Hfaiedh, Najla [2 ,3 ]
Giroux-Metges, Marie-Agnes [1 ]
Elfeki, Abdelfattah [2 ]
Talarmin, Helene [1 ]
机构：
[1] Univ Western Brittany, Physiol Dept EA1274, Fac Med & Hlth Sci, 22 Ave Camille Desmoulins,CS 93837, F-29238 Brest 3, France
[2] Fac Sci Sfax, Lab Environm Physiopathol, Valorizat Bioact Mol & Math Modeling, Rd Soukra Km 3-5,PB 171-3000, Sfax, Tunisia
[3] Fac Sci Gafsa, Lab Anim Eco Physiol, Gafsa 2112, Tunisia
来源：
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2017年 / 42卷 / 05期
关键词：
aspirin; antioxidant activities; Citrus limon; cytotoxicity; essential oil; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ACETYLSALICYLIC-ACID; OXIDATIVE STRESS; ANTIOXIDANT PROPERTIES; VOLATILE COMPONENTS; LIPID-PEROXIDATION; DEFENSE SYSTEMS; APOPTOSIS; PEEL; L;
D O I：
10.1139/apnm-2016-0515
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Aspirin, one of the widely used nonsteroidal anti-inflammatory drugs, is the most highly consumed pharmaceutical product in the world. However, it has several side effects in cells. This study was designed to investigate the antioxidative activity and cytoprotective effects of essential oil of Citrus limon (EOC) extracted from leaves against aspirin-induced damages in the rat small intestine epithelial cells (IEC-6). Biochemical indicators were used to assess cytotoxicity and oxidative damages caused by aspirin treatment on IEC-6. Our results showed that the chemical characterization of EOC identified 25 compounds representing 98.19% of the total oil. The major compounds from this oil were z-citral (53.21%), neryl acetate (13.06%), geranyl acetate (10.33%), and limonene (4.23%). Aspirin induced a decrease in cell viability as well as an increase in superoxide dismutase (SOD) and catalase (CAT) activities. Contrariwise, the co-exposure of cells to aspirin and EOC alleviated every above syndrome by an increase in cell survival and decrease in SOD and CAT activities. In conclusion, the essential oil of C. limon has a potent cytoprotective effect against aspirin-induced toxicity in IEC-6 cells.
引用
收藏
页码：479 / 486
页数：8
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