A Modeling Study of Glutamate Release of NMDA Receptors

被引:0
|
作者
Blackwell, Justin [1 ]
Su, Jianzhong [1 ]
Kavalali, Ege [1 ]
机构
[1] Univ Texas Arlington, Dept Math, Arlington, TX 76019 USA
关键词
Synapse modeling; Neurotransmission; Independent signaling; NMDA receptors; Diffusion equation; Chemical synapses; CENTRAL SYNAPSE; POOL;
D O I
10.1007/978-90-481-9695-1_47
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In this chapter we will use a mathematical model to simulate spontaneous and evoked neurotransmission to determine how receptor location on presynaptic density can activate distinct sets of NMDA receptors and signal independently to the postsynaptic side. We will also examine how the release rate of the neurotransmitter Glutamate will affect post-synaptic currents by varying the fusion pore size at the presynaptic side.
引用
收藏
页码:301 / 305
页数:5
相关论文
共 50 条
  • [21] Molecular modeling and comparative analysis of amino-terminal domain of NMDA ionotropic glutamate receptors
    Belenikin, M. S.
    Proceedings of the Fourth International Conference on Bioinformatics of Genome Regulation and Structure, Vol 1, 2004, : 242 - 243
  • [22] STRUCTURAL AND FUNCTIONAL-CHARACTERIZATION OF NMDA RECEPTORS AND METABOTROPIC GLUTAMATE RECEPTORS
    MASU, M
    NAKANISHI, S
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S256 - S256
  • [23] OPPOSITE PRESYNAPTIC REGULATIONS BY GLUTAMATE THROUGH NMDA RECEPTORS OF DOPAMINE SYNTHESIS AND RELEASE IN RAT STRIATAL SYNAPTOSOMES
    DESCE, JM
    GODEHEU, G
    GALLI, T
    GLOWINSKI, J
    CHERAMY, A
    BRAIN RESEARCH, 1994, 640 (1-2) : 205 - 214
  • [24] NMDA and metabotropic receptors regulate tyrosine phosphorylation of striatal glutamate receptors
    Orlando, LR
    Dunah, AW
    Standaert, DG
    Penney, JB
    Young, AB
    NEUROPHARMACOLOGY, 1999, 38 (10) : A33 - A33
  • [25] Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
    Hanada, Takahisa
    BIOMOLECULES, 2020, 10 (03)
  • [26] Exacerbation of neuronal cell death by activation of group 1 metabotropic glutamate receptors: Role of NMDA receptors and arachidonic acid release
    Allen, JW
    Vicini, S
    Faden, AI
    EXPERIMENTAL NEUROLOGY, 2001, 169 (02) : 449 - 460
  • [27] Metabotropic glutamate receptors inhibit microglial glutamate release
    McMullan, Stephen M.
    Phanavanh, Bounleut
    Li, Gary Guo
    Barger, Steven W.
    ASN NEURO, 2012, 4 (05): : 323 - 330
  • [28] EXTRASYNAPTIC NMDA RECEPTORS DETECT SPIKES AND EXTRACELLULAR GLUTAMATE
    Wu, Yu-Wei
    Grebenyuk, Sergei
    Rusakov, Dmitri
    Semyanov, Alexey
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009, 59 : 233 - 233
  • [29] Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts
    Hinoi, E
    Fujimori, S
    Takarada, T
    Taniura, H
    Yoneda, Y
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 297 (03) : 452 - 458
  • [30] Glutamate and cysteinylglycine effects on NMDA receptors: Inhibition by ethanol
    Morris, J
    Leslie, SW
    ALCOHOL, 1996, 13 (02) : 157 - 162