Immune Memory: the Basics and How to Trigger an Efficient Long-Term Immune Memory

被引：3
|
作者：
Beverley, P. C. L. [1 ]
机构：
[1] Univ Oxford, Oxford OX1 3SY, England
来源：
JOURNAL OF COMPARATIVE PATHOLOGY | 2010年 / 141卷
关键词：
kinetics; memory; protection; B-CELL SUBSETS; T-CELLS; RAPID TURNOVER; ANTIGEN; 85A; LIFE-SPAN; VACCINATION; KINETICS; TUBERCULOSIS; HUMANS; BCG;
D O I：
10.1016/j.jcpa.2009.09.008
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Immunological memory consists of expanded clones of T and B lymphocytes that show an increased rate of cell division and shortened telomeres compared with naive cells. However, exhaustion of clones is delayed by kinetic heterogeneity within clones and altered survival and up-reulation of telomerase. Prolonged maintenance of protective B-cell immunity is T-cell dependent and requires a balance between plasma cells and memory B cells. Protective T-cell immunity also requires correct quality of T cells and that they are located appropriately. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：S91 / S95
页数：5
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