Synthesis of imidazo[1′,5′:1,2]pyrido [3,4-b]indole derivatives

被引：2

作者：

Solymár, M ^{[1
]}

Palkó, M ^{[1
]}

Martinek, T ^{[1
]}

Fülöp, F ^{[1
]}

机构：

[1] Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary

来源：

MONATSHEFTE FUR CHEMIE | 2002年 / 133卷 / 11期

关键词：

beta-carbolines; hydantoins; thiohydantoins; keto-enol tautomerism;

D O I：

10.1007/s007060200114

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reactions of 1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid and its ethyl ester with alkyl and aryl isothiocyanates under mild conditions resulted in the corresponding thiohydantoin-fused tetrahydro-beta-carbolines. Treatment of the ethyl ester with isocyanates furnished ethyl 2-alkyl- or arylearbamoyl-1,2,3,4-tetrahydro-beta-carboline-1-carboxylates which were transformed to hydantoinfused tetrahydro-beta-carbolines. The structures of the thiohydantoin compounds, involving two conformers and the presence of keto-enol tautomerism, were determined by NMR spectroscopy.

引用

页码：1423 / 1430

页数：8

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