ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

被引：136
|
作者：
Casini, Angela
Mastrobuoni, Guido
Temperini, Claudia
Gabbiani, Chiara
Francese, Simona
Moneti, Gloriano
Supuran, Claudiu T.
Scozzafava, Andrea
Messori, Luigi
机构：
[1] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, Italy
[2] Univ Florence, Mass Spectrometry Ctr, I-50019 Sesto Fiorentino, Italy
来源：
CHEMICAL COMMUNICATIONS | 2007年 / 02期
关键词：
D O I：
10.1039/b611122j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 angstrom resolution, reveals selective platination of imidazole N epsilon of His15.
引用
收藏
页码：156 / 158
页数：3
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