Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine

被引:0
|
作者
Vasile, Danut [1 ]
Iancu, Raluca [2 ]
Bogdanici, Camelia [3 ]
Ungureanu, Emil [4 ]
Ciobotea, Dana [5 ]
Ciuluvica, Radu [4 ]
Iancu, George [6 ]
机构
[1] Carol Davila Univ Med & Pharm Bucharest, Fac Gen Med, Dept Surg, 37 Dionisie Lupu Str, Bucharest 020021, Romania
[2] Carol Davila Univ Med & Pharm Bucharest, Fac Gen Med, Dept Ophthalmol, 37 Dionisie Lupu Str, Bucharest 020021, Romania
[3] Grigore T Popa Univ Med & Pharm Iasi, Fac Gen Med, Ophthalmol Discipline, 16 Univ Str, Iasi 700115, Romania
[4] Carol Davila Univ Med & Pharm Bucharest, Fac Gen Med, Dept Anat, 37 Dionisie Lupu Str, Bucharest 020021, Romania
[5] Victor Babes Univ Med & Pharm, Dept Surg, Ophthalmol Discipline, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[6] Carol Davila Univ Med & Pharm Bucharest, Fac Gen Med, Dept Obstet & Gynecol, 37 Dionisie Lupu Str, Bucharest 020021, Romania
来源
REVISTA DE CHIMIE | 2017年 / 68卷 / 02期
关键词
Hyaluronic acid; Glycosaminoglycan; Viscoelastic properties; BROAD RANGE; OSTEOARTHRITIS; FIBROBLASTS; DERIVATIVES; HYDROGELS;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Hyaluronic acid is a mucopolysaccharide encountered in most body fluids and extracellular matrix. The aim of our review is to summarize current evidence about chemico-physical properties of hyaluronic acid, highlighting biomedical applications of hyaluronan derivatives. It is a glycosaminoglycan made of repeating disaccharide units containing a carboxylate group, four hydroxyl groups and one carboxylate group, with hydrophilic properties. Its particular structure with multiple coils forming an entangled network results in unique pseudoplastic and viscoelastic characteristics. Its viscous and elastic behavior, depending on the applied strain, makes hyaluronan widely applicable in biomedical field. The large amount of functions and applications is determined by the physico-chemical properties, which allows a polymorphism of the hyaluronic add structures depending on the molecular weight variations, concentration and ionic status. It is currently used in ophthalmology, orthopedics and rheumatology, in plastic surgery, surgery and otolaryngology as well. Already widely used in clinical practice, hyaluronic acid proves to be often the best solution for difficult medical problems. Future developments in nanomedicine and drug delivery linked to hyaluronic acid are emerging.
引用
收藏
页码:384 / 386
页数:3
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