Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong

被引：15

作者：

Kam, KM ^{[1
]}

Kam, SSY ^{[1
]}

Cheung, DTL ^{[1
]}

Tung, VWN ^{[1
]}

Au, WF ^{[1
]}

Cheung, MM ^{[1
]}

机构：

[1] Dept Hlth, Publ Hlth Lab Ctr, Pathol Serv, Sexually Transmitted Dis Lab, Kowloon, Hong Kong, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 01期

关键词：

D O I：

10.1128/AAC.47.1.436-439.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87-->Arg were associated with a higher level of resistance than a Ser-87-->Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA, conferring Ala-92-->Pro and Asp-95-->Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes-11 to 19 repeats-were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity.

引用

页码：436 / 439

页数：4

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