Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong

被引：15
|
作者：
Kam, KM [1 ]
Kam, SSY [1 ]
Cheung, DTL [1 ]
Tung, VWN [1 ]
Au, WF [1 ]
Cheung, MM [1 ]
机构：
[1] Dept Hlth, Publ Hlth Lab Ctr, Pathol Serv, Sexually Transmitted Dis Lab, Kowloon, Hong Kong, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 01期
关键词：
D O I：
10.1128/AAC.47.1.436-439.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87-->Arg were associated with a higher level of resistance than a Ser-87-->Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA, conferring Ala-92-->Pro and Asp-95-->Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes-11 to 19 repeats-were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity.
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页码：436 / 439
页数：4
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