Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a Potent Target for Breast Cancer Therapy

被引：19
|
作者：
Lian, Caixia [1 ]
Ruan, Lingling [2 ]
Shang, Dongsheng [1 ]
Wu, Yanfang [1 ]
Lu, Yongjin [2 ]
Lu, Peng [1 ]
Yang, Yuhua [2 ]
Wei, Yajun [2 ]
Dong, Xiaojing [2 ]
Ren, Dewan [2 ]
Chen, Keping [1 ]
Liu, Hanqing [2 ]
Tu, Zhigang [1 ]
机构：
[1] Jiangsu Univ, Inst Life Sci, Zhenjiang, Peoples R China
[2] Jiangsu Univ, Sch Pharm, Zhenjiang, Peoples R China
来源：
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | 2016年 / 31卷 / 03期
关键词：
angiogenesis; breast cancer; EGFR; HB-EGF; targeted therapy; triple-negative breast cancer; CELL LUNG-CANCER; TYROSINE KINASE INHIBITORS; CARBOXY-TERMINAL FRAGMENT; MEMBRANE-ANCHORED FORM; FACTOR EGF RECEPTOR; HB-EGF; IN-VITRO; NUCLEAR TRANSLOCATION; EPITHELIAL-CELLS; ERBB RECEPTORS;
D O I：
10.1089/cbr.2015.1956
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) belongs to the EGF family and exhibits its activity after binding to its receptors in autocrine, paracrine, and juxtacrine interactions. HB-EGF plays important roles in several biological and pathological processes, such as wound healing, blastocyst implantation, atherosclerosis, and heart development. Clinical studies have shown that HB-EGF is closely correlated with tumorigenesis, metastasis, and drug resistance in breast cancer. Specifically, targeted inhibition of HB-EGF improves the therapeutic efficacy and suppresses the tumor progression. This review discusses the importance of HB-EGF in mammary carcinoma progression and the potential value of HB-EGF as a therapeutic target for breast cancer treatment.
引用
收藏
页码：85 / 90
页数：6
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