Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a Potent Target for Breast Cancer Therapy

被引：19

作者：

Lian, Caixia ^{[1
]}

Ruan, Lingling ^{[2
]}

Shang, Dongsheng ^{[1
]}

Wu, Yanfang ^{[1
]}

Lu, Yongjin ^{[2
]}

Lu, Peng ^{[1
]}

Yang, Yuhua ^{[2
]}

Wei, Yajun ^{[2
]}

Dong, Xiaojing ^{[2
]}

Ren, Dewan ^{[2
]}

Chen, Keping ^{[1
]}

Liu, Hanqing ^{[2
]}

Tu, Zhigang ^{[1
]}

机构：

[1] Jiangsu Univ, Inst Life Sci, Zhenjiang, Peoples R China

[2] Jiangsu Univ, Sch Pharm, Zhenjiang, Peoples R China

来源：

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | 2016年 / 31卷 / 03期

关键词：

angiogenesis; breast cancer; EGFR; HB-EGF; targeted therapy; triple-negative breast cancer; CELL LUNG-CANCER; TYROSINE KINASE INHIBITORS; CARBOXY-TERMINAL FRAGMENT; MEMBRANE-ANCHORED FORM; FACTOR EGF RECEPTOR; HB-EGF; IN-VITRO; NUCLEAR TRANSLOCATION; EPITHELIAL-CELLS; ERBB RECEPTORS;

D O I：

10.1089/cbr.2015.1956

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) belongs to the EGF family and exhibits its activity after binding to its receptors in autocrine, paracrine, and juxtacrine interactions. HB-EGF plays important roles in several biological and pathological processes, such as wound healing, blastocyst implantation, atherosclerosis, and heart development. Clinical studies have shown that HB-EGF is closely correlated with tumorigenesis, metastasis, and drug resistance in breast cancer. Specifically, targeted inhibition of HB-EGF improves the therapeutic efficacy and suppresses the tumor progression. This review discusses the importance of HB-EGF in mammary carcinoma progression and the potential value of HB-EGF as a therapeutic target for breast cancer treatment.

引用

页码：85 / 90

页数：6

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